NirodhaAvidya

How is that different from Spotify producing their own AI-gen music? Seems like that’s 3-4 minutes of listening that otherwise would’ve been spent listening to an artist.

Fraking toasters

“Thomson Reuters, best known for its media outlet and legal research tools, provides an investigative tool to immigration enforcers. Its Minnesota employees want that to stop.”

Isn’t it odd that when we speak of the “wealth” of the lower class it’s always in comparison to the rich. Like, I never think to myself or say to my peers, my $1000 in savings is my amount of “wealth”.

Look at big shot over here with $1000 and an expectation of retiring.

It’s an interesting metaphor and makes for a good read.

It’s not a monopoly, but it is a cartel.

ABSTRACT

Chemodynamic therapy (CDT) is an emerging cancer treatment that employs transition metal–based nanoagents to catalyze the conversion of elevated intracellular hydrogen peroxide in malignant cells into cytotoxic hydroxyl radicals (•OH) via Fenton-like reactions. Recent developments have also introduced CDT agents that generate singlet oxygen (1O2) through the Russell mechanism. However, current nanoplatforms efficiently produce either •OH or 1O2, but not both, and often exhibit suboptimal catalytic activity, thereby limiting the sufficient production of reactive oxygen species (ROS) required for cancer eradication. This report introduces a ferrous metal–organic framework, Fe(II)-TCPP (tetrakis(4-carboxyphenyl)porphyrin), as the first nanoagent capable of simultaneously and effectively generating •OH and 1O2 through dual catalytic pathways. Its nanoneedle-like morphology increases the surface area and promotes enhanced ROS production. Cell studies demonstrated selective intracellular generation of •OH and 1O2 in cancer cells, resulting in targeted cytotoxicity while sparing non-malignant cells. Systemic administration of Fe(II)-TCPP in a breast cancer mouse model resulted in preferential tumor accumulation, robust intratumoral ROS generation, cancer eradication, and prevention of recurrence without systemic toxicity. These findings mark a foundational advance in CDT nanoagents by integrating Fenton and Russell mechanisms into a single platform, enabling the design of multifunctional catalysts with enhanced ROS output and therapeutic efficacy.

ABSTRACT

Chemodynamic therapy (CDT) is an emerging cancer treatment that employs transition metal–based nanoagents to catalyze the conversion of elevated intracellular hydrogen peroxide in malignant cells into cytotoxic hydroxyl radicals (•OH) via Fenton-like reactions. Recent developments have also introduced CDT agents that generate singlet oxygen (1O2) through the Russell mechanism. However, current nanoplatforms efficiently produce either •OH or 1O2, but not both, and often exhibit suboptimal catalytic activity, thereby limiting the sufficient production of reactive oxygen species (ROS) required for cancer eradication. This report introduces a ferrous metal–organic framework, Fe(II)-TCPP (tetrakis(4-carboxyphenyl)porphyrin), as the first nanoagent capable of simultaneously and effectively generating •OH and 1O2 through dual catalytic pathways. Its nanoneedle-like morphology increases the surface area and promotes enhanced ROS production. Cell studies demonstrated selective intracellular generation of •OH and 1O2 in cancer cells, resulting in targeted cytotoxicity while sparing non-malignant cells. Systemic administration of Fe(II)-TCPP in a breast cancer mouse model resulted in preferential tumor accumulation, robust intratumoral ROS generation, cancer eradication, and prevention of recurrence without systemic toxicity. These findings mark a foundational advance in CDT nanoagents by integrating Fenton and Russell mechanisms into a single platform, enabling the design of multifunctional catalysts with enhanced ROS output and therapeutic efficacy.

“At this scale, downstream risks include account takeovers, targeted phishing, credit fraud, SIM swaps, and long-tail privacy harms. Industry-wide, the case underlines how third-party identity vendors have become critical infrastructure and can become single points of catastrophic failure,” our team explained."

Wouldn’t Username + Password + SIM = 2FA password reset?

Same costume designer from The Cell (2000). Beautiful movie. Wicked costumes.

God Damned, that is pure fucking evil. Like, I can’t even… Just literal evil.

How’s this compare to Obsidian or Joplin?

“Unicorn Jelly is a philosophical science fiction manga strip which tells a metaphoric and purposeful story with a definitive beginning and ending. It was published every weekday at Midnight from 2000 to 2003.”

Seconded. If true, my paranoia will be justified and prove to be woefully insufficient.

I miss the old days of DA. Countless hours of scrolling to find the perfect wallpaper or art for my TTRPG games. Now I mostly use Patreon or occasionally ArtStation. But it not the same.

Every moment I spend with you is better than the next.